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The NA was treated as a continuous trait in the statistical modeling.
Although consistent with our observations for weight gain as a continuous trait, the interaction observed in the case-noncase analyses was only borderline significant after correcting for multiple testing (P = 0.002).
We tested for association with BP as a continuous trait and hypertension in all cohorts under a dominant model, with the prior hypothesis that carriers of rs765250 allele A (A/A+A/G verses G/G) would have higher BP levels and be at increased risk for EH compared to G/G homozygotes – as determined from our primary analysis in the BRIGHT study.
SSD was treated as a continuous trait using size dimorphism index (SDI) [ 24].
Two polymorphisms within two genes were found to be significantly associated with this growth response, assessed as a continuous trait (Table 2).
However, when BMI was analyzed as a continuous trait, then the p value for interaction was 0.04 for total serum cholesterol and less than 0.001 for HDL-cholesterol.
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Fasting triglycerides were analysed as a continuous traits but the result were not associated with rs2513280 (P = 0.207).
The OU model incorporates stabilizing selection as a constraint and quantifies the evolution of a continuous trait X as d X t) = α[ θ – X t)]d t + σd B t), where σ captures the stochastic evolution of BM, and α determines the rate of adaptive evolution towards an optimum trait value θ [ 52, 53].
Other approaches have shown that multiple low frequency coding variants in one or more genes accumulate at the tails of a population distribution for a continuous trait such as lipid levels [ 8] or blood pressure [ 9].
As a proportion, basic specificity is a continuous trait ranging from 'monospecificity' (the epiphyte species can only inhabit a single tree species) over 'intermediate basic specificity' (it can inhabit a subset of tree species) to 'complete basic generality' (it can inhabit all tree species).
Genetic evidence indicates that adiposity is a continuous trait, much like other life-history traits such as stature and the timing of puberty (Elks et al., 2010b; Lango Allen et al., 2010).
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