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We speculate the difference in affinity of tapasin and TAPBPR for MHC class I may have evolved as a consequence of the distinct cellular environment the two peptide exchange catalysts function: tapasin functioning in the context of the PLC, where other proteins collectively form a mutually supportive interaction scaffold, and TAPBPR functioning outside the confines of the PLC.
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The existence of species, i.e. entities such that genetic exchanges are much less frequent between than within, appears universal across current biodiversity, probably as a consequence of the existence of distinct, discrete ecological niches.
Hybridisation, even between closely related species [10], frequently brings about an abrupt shift in the regulatory networks, as a consequence of the interaction between distinct parental gene hierarchies [11].
The same symbiovar may be present in distinct species as a consequence of the lateral transfer of symbiotic plasmids or islands.
Previous studies also suggested that Vpr can induce apoptosis in distinct human cells as a consequence of the prolonged cell cycle arrest [3], [4].
The separation takes place as a consequence of the interplay between the flow characteristics in the branched geometry and the distinct inertial properties of the dragged particles.
Distinct patterns of leaf initiation arise as a consequence of the self-organizing properties of the auxin transport system [ 22, 23].
Although some of the graphene electronic properties are present in the CNCs, deviations are always manifested as a consequence of the different atomic arrangements, the finite-size of the nanocones, and also the possible point symmetry of the distinct cones.
We proposed that the observed distinct Gag assembly patterns could be the result of differential intracellular Gag trafficking as a consequence of the different pathways used for the export of HIV-1 Gag mRNA from the nucleus.
As an important consequence of the distinct tertiary contacts between DNA segments, supercoiled DNA of opposite signs must display drastically different physical properties.
Hence, anti-nuclear antibodies appear to arise as a consequence of two distinct processes genetically programmed selection of specific CDR charge motifs into the primary immunoglobulin repertoire, with secondary contribution from somatic mutation.
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