Since both effects are a consequence of the deficient vasculature, they may co-exist anyway.
As a consequence of the inability of ATMIN-deficient cells to clear replication-induced stress, these cells displayed an increase in lagging chromatin and anaphase bridges after aphidicolin treatment (Fig. 5C).
Thus, observing no overt spontaneous phenotypes as a consequence of combined deficiency of Mmp13 and Plau, we next initiated a wound healing study in which we inflicted standardized 20 mm-long full-thickness incisional skin wounds on wild-type (n = 15), Mmp13-deficient (n = 19), Plau-deficient (n = 16) and Mmp13 Plau double-deficient (n = 15) mice.
Furthermore, these analyses even revealed elevated sphingomyelin levels in COX-deficient cells as a consequence of the increased cellular ceramide content.
As a consequence of the functional link between HMGA1 and RBP4, a significant increase in Glut4 mRNA and protein was observed in both skeletal muscle and adipose tissues from Hmga1-deficient mice compared with controls.
From this perspective, men's propensity to die at a younger age than women is commonly explained as a consequence of their deficient behaviour and lifestyle [ 7].
As a consequence of deficient financing, physicians face limitations in decision-making and fibrinolysis in ACS with persistent ST-elevation is applied relatively rarely and depends more on the hospital's actual budget situation than on patients' medical needs.
Impaired proinflammatory cytokine production without any reduction in cytokine mRNA levels in tnc− / − cells led us to investigate whether tnc− / − BMDMs exhibit abnormal intracellular cytokine levels as a consequence of deficient secretion.
This suggests that the spermatogenic defects we observe in Ercc1 deficient mice are not a consequence of the lack of the NER functions of ERCC1 but are instead the consequence of its additional repair roles, such as in HR.
In Grem1-deficient embryos, Six2 expression was completely lost by E13.5 as a consequence of eliminating the metanephros by apoptosis (Figure 5B and Figure 4B) [17].
