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Recently, Virno et al. [ 35] assessed the effect of ibopamine, a D1-dopamine agonist, on IOP in offsprings of parents with POAG as a consequence of outflow structures impairment.
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Hydrocephalus most commonly occurs as a consequence of obstructed CSF outflow, and is routinely treated by insertion of a ventriculo-peritoneal shunt diverting the excessive fluid from the ventricles into the peritoneal cavity in the abdomen8.
(b) Conduit widening is further amplified by intrusion of warmer ocean water, and (c) sedimentation forms an esker at the conduit's portal as a consequence of conduit widening and decreasing water outflow speed.
This latter behaviour parallels the observations made in otherwise normal organs in which a pressure overload arises as a consequence of an obstacle to the venous outflow, such as in the liver of patients with right heart failure [15] and in the spleen in case of portal hypertension, both in animal models [16] and in vivo [17, 18, 19].
In this model, channel floor collapse and secondary chaotic terrain formation would have taken place as a consequence of instabilities arising during their exhumation by outflow channel dissection.
IOP reduction after clear corneal phacoemulsification is considered to be a consequence of increased outflow of aqueous humor due to an increased angle width and tensioning of the trabecular meshwork.
Splenomegaly is related not only to blood congestion as a consequence of increased portal pressure and augmented resistance to splenic vein outflow but also to multiple other histopathologic changes, such as arterial aneurysms [ 22] and concern with endothelin [ 23], and the immunologic pathway from the liver [ 24].
Although increasing the Vm of GLUT2 has a positive effect on water inflows and outflow, its sensitivity is reduced by 3-OMG accumulation in the vestibule as a consequence of the low D23, which slows glucose transit through the vestibule and masks the high Vm.
The aim of the present work is the investigation in-vitro of the fluid dynamic modifications occurring as a consequence of the morphological changes typically induced in the aortic root by MS. A mock-loop reproducing the left ventricle outflow tract and the aortic root was used to measure time resolved velocity maps on a longitudinal symmetry plane of the aortic root.
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