The phrase "as a consequence of functional" is not correct and lacks clarity in written English.
It may be intended to describe an outcome resulting from a functional aspect, but it needs additional context or completion to be usable.
Example: "As a consequence of functional changes in the system, we observed improved performance metrics."
Alternatives: "due to functional" or "as a result of functional".
Remarkably, this modification is not required for NER, but rather occurs as a consequence of functional NER, as several defined NER mutants did not result in UV-induced H2A ubiquitination.
Whereas in cervical cancer strong p16INK4a overexpression can be observed in virtually all high-grade dysplastic and cancerous cases as a consequence of functional inactivation of pRb by the E7 protein of high-risk HPV, high p16INK4a protein levels characterise only a subgroup of patients with advanced-stage ovarian cancers associated with a worse prognosis.
These models consistently assume similar evolutionary fates of the two gene copies following gene duplication, either as a consequence of relaxed functional constraint [ 51] or by a succession of relaxed functional constraint and positive selection along both lineages [ 52].
Our work suggests that modularity can emerge as a consequence of increasing functional constraints.
13, 14 This may arise as a consequence of the functional involvement of the thalamus in seizures.
Preliminary genetic data on AGAP009368 (Plugin) provide further indications that different selective forces could act to change the rate of evolution of A. gambiae male-expressed genes, putatively as a consequence of different functional phenotypes.
As a consequence of the functional link between HMGA1 and RBP4, a significant increase in Glut4 mRNA and protein was observed in both skeletal muscle and adipose tissues from Hmga1-deficient mice compared with controls.
While this may suggest that HD1 proteins have additional roles that do not require heterodimerization (a possibility so far poorly explored in basidiomycetes), another possibility is that this gene is losing its mating specific role in species of clade B as a consequence of relaxed functional constraints.
Whilst the majority of gene duplicates were probably lost as a consequence of their functional redundancy, some were fixed in the genome by the gain of new biological functions or partitioning the function of the ancestral counterpart and this may be the case for the secretin family GPCRs and their ligands [ 8, 17, 83].
As a consequence of microglial activation, functional changes may occur in the motor cortex.
In another perspective, precursors of old miRNAs have acquired a sequence composition for successful recognition and processing by all parts of the miRNA-processing apparatus over long-term evolution, and as a consequence of selection for functional structures, ss-motifs extracted from old pre-miRNAs may be more "informative" for feature analysis.
