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The latter scenario is possible as a consequence of duplication events, under a model of subfunctionalization.
The bridging edge is an evolutionary novelty created as a consequence of duplication, possibly but not necessarily associated with ancestral proteins prone to homodimerisation.
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These data reinforce the intepretation that the TSP-3, TSP-4 and TSP-5 genes have evolved as a consequence of duplications of the same ancestral genomic region.
When regulatory interactions are considered using protein interactions matching binding sites, it has been shown that the abundance of some well-known motifs (such as feed-forward loops) is largely a consequence of duplication and divergence (Cordero and Hogeweg 2006).
It can also be a consequence of duplication followed by in-frame fusion, resulting in tandem duplications.
As a consequence of the duplication mechanism, the two centrioles in a typical interphase cell are of different ages and have different functions.
In other vertebrates and mammals the number of functionally active loci varies, as a consequence of gene duplication and suppression events [4].
For example, four CERV-K where found on the Y chromosome, three of which were found within an apparently low complexity repeat region, as a consequence of DNA duplication (i.e., CERV-K "Y chromosome quartet" in Figure 1).
Thus it is unlikely that Mel1c/GPR50 evolved as a consequence of gene duplication.
It arose when this inversion was generated as a consequence of the duplication of a 4.3-kb segment containing a fragment of gene CG1208.
This gene arose at the time of the inversion generation as a consequence of the duplication of a 7.1-kb segment originally containing three genes: CG1792, Dvir\GJ23094 and pasha (Additional file 3).
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