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Our analyses also revealed that haplotypes in current populations carrying high- and low-expression phenotypes were nearly exclusively evolved early in human evolutionary history (Figure 4), likely as a consequence of balancing selection.
HLA allelic diversity is earmarked by the dominance of nonsynonymous SNPs in the open reading frames, often as a consequence of balancing selection by a variety of human infectious diseases [52].
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The time evolution of species in the gaseous phase after autoignition shows similar trends for all the diameters and dilution levels investigated here with the peak of temperature and OH mass fraction moving towards the droplet surface as a consequence of the balance between fuel production and consumption.
As a consequence of the balance-of-power strategy, the U.S. went to war against Japan in WWII; sought to prevent the communists from winning the post-WWII civil war in China; intervened in another civil war in Korea in 1950-53, and then fought an unnecessary war with China after refusing to settle for saving South Korea from the North Korean attack.
Some believed that AARs evolve in a largely neutral fashion [ 18], partly as a consequence of the balance between replication slippage and point mutations [ 6].
All these data may be interpreted as a consequence of a balance between drift and homogenisation mechanisms acting on these subtelomeric genes.
As a consequence of this balance, the prevention of NIHL requires pharmacological combination treatment to address both apoptotic and necrotic pathways.
As a consequence of an altered balance between synthesis and degradation, the amounts of this protein are abnormally low in advanced and poorly differentiated neoplasms [ 3].
There are a number of lines of evidence for this; first (and most importantly) Seoane et al. have shown that in colorectal cancer cell lines depletion of C-MYC reduces apoptosis as a consequence of altering the balance of downstream effectors of P53 signalling.
The adopted recommendation is that "As a consequence of its analysis balance of benefits and risks of the symbol, the Paediatric Committee was unable to recommend to the EC any symbol for which the benefits would outweigh the risks identified and dominated by potentially fatal medication errors".
The study moreover suggests that a moderate up-regulation of PPARα target genes involved in fatty acid uptake and oxidation in liver and muscle as a consequence of a negative energy balance might not interfere with milk production of sows.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com