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These features highlight the use of our in vitro culture model as a complementary testing platform in conjunction with animal models, addressing key reduction and replacement goals of the future.
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Immunohistochemical evaluation of p53 staining patterns has been considered as a complementary test for dysplasia in ulcerative colitis-related colorectal cancer surveillance, but usefulness would be particularly important if it were a marker associated with a poor prognosis.
However, they could only be used as a complementary test till now.
We therefore recommend using the variance-based tests as a complementary test to the standard mean-based test.
Increasingly, PET is proving to be of immense value as a complementary test to CT in solving such problem cases.
We have shown by simulations that the variance-based test captures different signals than the standard association test, thus can be used as a complementary test.
As a complementary test, and also to deal with those experimental datasets lacking a carbon-balance, we perform a different consistency analysis based on Possibilistic MFA.
A combination of methylation-regulated TSGs including RASSF1A, P16, and EBV-based markers could serve as a complementary test for the early detection of NPC [ 47, 61].
ESBL production was screened at the same time by the double disc synergy method as a complementary test for automated systems, at each centre.
As a complementary test, we also estimated the time required to destroy PIPSL's ORF in one half of all simulations, t1/2 [ 19].
Urinary mutagenicity was also assessed in our study as a complementary test to evaluate the mutagenic potential of the collected urine.
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