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MED12 was identified as a common determinant of drug resistance using 24,000 shRNAs targeting 8000 human genes in a lung cancer line harboring a translocation between EML4 and the kinase ALK, which is sensitive to ALK inhibitors PF-02341066 (crizotinib) and NVP-TAE684.
While a key 2007 paper made the case for ROS, specifically hydroxyl radicals, as a common determinant of death induced by diverse antibiotics, three recent papers presented data inconsistent with this model.
As the ovulated eggs in reared rainbow trout do not usually oviposit naturally, post-ovulatory aging of the eggs is widely accepted as a common determinant for egg quality [ 20- 22].
The Erg24 gene, encoding a C-14 sterol reductase also involved in ergosterol biosynthesis, was also identified as a common determinant of resistance to ethanol, acetic acid, vanillin and furfural; however, the expression of this gene was dispensable for yeast growth in the WSH and only had a slight effect on the fermentation performance of this substrate.
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Because PM exposure simultaneously affects multiple aspects of CVD, it is plausible that exposure affects a common determinant of CVD, such as the endothelium.
Our analysis revealed that low proliferation as quantified by low levels of E2F1 represented a common determinant of patients with good prognosis.
A common determinant of costs for both perspectives was the length of treatment.
Tumor hypoxia is a common determinant of resistance to cytotoxic therapies and metastatic behavior.
The strong association between concurrent BV and genital ulceration and incident GWs supports a common determinant.
Regardless of the modality prescribed, a common determinant of drug clearance in CRRT is protein binding.
We investigated whether variation in MTNR1B, which was recently identified as a common genetic determinant of fasting glucose levels in healthy, diabetes-free individuals, is associated with measures of beta cell function and whole-body insulin sensitivity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com