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ROS has been shown as a classical inducer of the MAPK family members, through a variety of mechanisms including activation of MAP3K, such as ASK1 and oxidation of MKPs[6], [47].
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Lysosomal protein degradation was estimated by measuring [C]valine release from cells treated with and without EST+PepA as well as during starvation, a classical inducer of autophagy (Fig. 1I).
Compared with hypoxic treatment, a classical inducer of HIF-1α, LPS stimulation in normoxia induces a greater amount of HIF-1α protein and mRNA in DCs.
We also treated the cells with H2O2, a classical inducer of oxidative stress.
Heat shock is a classical inducer of proteotoxic stress by causing alterations in protein folding, leading to apoptotic cell death when a critical threshold has been exceeded [46].
Tn is a classical inducer of ER stress by virtue of its inhibitory effect on N-glycosylation of nascent proteins destined to membranes or extracellular secretion [2].
We then treated mice with rapamycin, a classical inducer of mTOR-dependent autophagy, by administrating 2 mg/kg rapamycin through intraperitoneal (IP) injection at a frequency of three times per week, as previously used in the models of brain injury or prion disease.
Rapamycin (Rapa), a mammalian target of rapamycin (mTOR) inhibitor, has been used as a classical autophagy inducer.
Tunicamycin has been commonly employed as a classical pro-apoptotic inducer through the ER stress pathway.
He has identified as a classical liberal.
As a classical singer, Turunen sings with classical vocal technique.
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