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Notably, the shRNAs or gRNAs that enrich and deplete in vivo differ strikingly from those that enrich and deplete in culture, implicating the tumor microenvironment as a central contributor to tumors homeostasis.
Oxidative stress is recognized as a central contributor to neuronal injury.
When tested using lung-derived transcriptomic data from CS-exposed mice, it explained a large proportion (88%) of the observed significant mRNA expression changes, and mechanistically confirmed the role of NRF2, a known mediator of the oxidative stress response, as a central contributor to the CS-induced stress response.
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Finally, followers value a central contributor because of its grip on customers.
Inflammation is a central contributor to the pathogenesis of CF pulmonary disease.
Isiah Thomas, the former Knicks executive and coach who was a central contributor to the disarray from which the franchise is still struggling to emerge, is returning to the organization as a part-time consultant, the team announced Friday.
Lack of sleep can be dangerous in other ways: it is a central contributor to CEO burnout.
Food prices, for instance, were a central contributor to a 4.4 percent rise in producer prices in 2009.
No matter the mechanism of Hippo pathway inactivation, cancer cells frequently exhibit hyperactive YAP, suggesting that YAP is a central contributor to tumorigenesis.
Mentors were not always a primary source of feedback or a central contributor to success.
While prior research has often dealt with SOIs in large firms, the last decade has begun to generate broad knowledge on the specificities of SOIs in small and medium sized enterprises (SMEs) as they are increasingly recognized as central contributors to sustainable development.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com