Sentence examples for aryl bromide from inspiring English sources

Subsequent copper-catalysed N-arylation of this key intermediate with the appropriate aryl bromide or iodide, followed by deprotection and methylation of the amine side chain where necessary gave the desired products.

Note that the reaction was performed in a sealed vial to allow temperature elevation to 90 °C, and to achieve full conversion of the aryl bromide it was necessary here (and in the following arylations) to use two equivalents of the ketone, which could be recovered easily after the reaction was complete.

This synthesis features a flexible palladium-catalyzed enolate arylation as the key step, and hence by substitution of the aryl bromide and ketone coupling partners, analogous syntheses of pseudocoptisine and palmatine (in 36%and62%62 % yields respectively), and of an unnatural fluorinated analogue (in 27 % yield) were readily achieved.

Fig. 3 Projection of FRET yields for palladium-catalyzed amination of aryl bromide [56] onto LKB-P map.

These utilised the oxidative Wittig-Heck reaction [11, 12] two sequential Heck-type reactions of aryl bromide [13] and organozinc reagents [10].

PBTPAs can be functionalized at both terminals separately by adding an aryl bromide or arylamine derivatives as a terminator, which enabled us to prepare the diblock copolymer PBTPA-block-PEO.

Hence, we were interested in the investigation of alternative methods suitable for aryl halides, and we developed a RuII-catalyzed method that enabled the use of aryl bromides and aryl iodides as arylation reagents.

Figure 3 summarizes the C3-selective arylation reactions with a range of aryl bromides under phosphine-free conditions.[ 17] Again, electron-donating, electron-withdrawing, sterically demanding, and heteroaryl bromides were all tolerated under the reaction conditions, giving isolated 3-arylpyrazolo[1,5-a]pyrimidines (3 a– q) in moderate to excellent yields.

Acyclic sp C H bonds adjacent to a free N H group were readily arylated by cyclometalation by employing [RuCl2 p-cymene)]2 and carboxylates with aryl bromides and iodides.

The obtained results reflect the reasonable activity of the catalyst 4 towards various aryl bromides 5b g.

The prepared [11C]MeLi was further used in a palladium catalyzed cross-coupling reaction with aryl bromides.