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The application of artificial loads to mammals and birds has been used to provide insight into the mechanics and energetic cost of terrestrial locomotion.
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Reducing the background level of the naturally engendered strain environment allows adaptive responses to artificial loading to be demonstrated at lower loads.
To avoid nodal instability, the nominal force method is adopted, which introduces artificial loading cases to simulate the effect of geometric imperfections.
Exercise was combined with artificial loading sufficient to cause bone gain in young and aged mice.
This mechanism has been the subject of a number of in vivo studies in animals in which artificial loads have been applied to the bones on one side and the modelling and remodelling responses in the loaded bones compared with those in the non-loaded contra-lateral pair [2 29].
We concluded that artificial loading of Sir2 to the plasmid either interfered with normal SAGA recruitment to the plasmid or that Sir2 constantly counteracts SAGA's function on the plasmid.
The mixed results of these studies could be partly influenced by the artificial nature of their loading regimes, for example differences in load position and the stress associated with the addition of artificial loads.
Aging impairs bones' response to artificial loading but not exercise.
In mice when ERα is absent the adaptive response to artificial loading in vivo is attenuated [14].
This comparison showed no additional effect of exercise on bone's response to artificial loading for any measured parameter in trabecular or cortical bone.
Since multiple factors known to influence bone formation appear to be differentially regulated by exercise and aging, we here explored the hypothesis that altering systemic and muscular factors through exercise will enhance aged bone's diminished response to artificial loading.
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