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Its predictive value on disease outcome, including both articular and cardiovascular issues, will have to be evaluated in upcoming prospective studies.
The findings of the GOAL study [ 1] remind us of unsolved issues about articular region-to-region differences in phenotype of what still appears to be a skeletal system-wide disorder of aging in the majority of patients with CPPD.
The device at issue — the Articular Surface Replacement, or A.S.R. — proved to be among the most flawed orthopedic devices sold in recent decades.
Therefore, excessive digestion of cartilage collagen is considered a critical issue in loss of articular cartilage in OA [ 62].
Post-traumatic arthritis is a frequent consequence of articular fracture.
Articular cartilage repair remains a challenging clinical issue because of the poor intrinsic ability of this tissue for repair.
Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair.
Vertical dimension of the face is important in issues of compressive forces exerted on articular structure, which was demonstrated by van Spronsen et al. [ 41].
Current cell based treatment for articular cartilage and osteochondral defects are hampered by issues such as cellular dedifferentiation and hypertrophy of the resident or transplanted cells.
Repair of articular cartilage damage has been a great clinical issue due to the difficulties of heal and regeneration once cartilage is damaged.
Should these issues be resolved satisfactorily, then intra-articular injection of MSCs suspended in HA could be a potentially useful therapeutic intervention for the treatment of spontaneous knee OA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com