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These studies demonstrate the beneficial effects of T3 in eliciting increased collagen production in articular chondrocytes in three-dimensional culture.
Conditional activation of β-catenin in articular chondrocytes in adult mice was found to result in articular cartilage destruction with accelerated terminal chondrocyte differentiation [ 16].
Similar matrix changes have been reported in articular cartilage in osteoarthritis [ 11, 12].
Specific activation of β-catenin in articular cartilage in a genetic mouse model also leads to an osteoarthritic phenotype [ 31].
In fact, there were weak or moderate correlations between age and T1ρ values in articular cartilage in the control group.
In this study we examined the expression of SVCT2, the only known Sodium coupled vitamin C transporter isoform present in articular cartilage, in human articular cartilage explants derived from both normal and osteoarthritis articular cartilage.
PE particles were injected repeatedly intra-articular in the knee until the dogs were killed after 8 weeks.
On the other hand, diffuse planar imaging patterns were confirmed to be intra-articular in all patients in our series and therefore do not warrant SPECT/CT or PET/CT for localisation.
Trabelsi, M., Cooper M.S. PP46 In vivo biodistribution of adult human mesenchymal stem cells I (MSCS-ah) labeled with 99MTC-HMPAO administered via intravenous and intra-articular in animal model.
Porous-coated cylindrical implants with an either plasma-sprayed closed-pore coating (Pl) or titanium fiber metal open-pore coating (Fi) were inserted intra-articular in exact fit or with a 0.75 mm peri-implant gap.
The procedure was unilateral in 91.6% of patients, intra-articular in 57.0%.
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