Intra-articular delivery of therapeutics to modulate osteoarthritis (OA) is challenging.
To determine the utility of silk fibroin (SF) microparticles as sustained release vehicles for intra-articular delivery.
Chitosan microspheres were formulated for the intra-articular delivery of lornoxicam in knee osteoarthritis, to minimize associated side-effects after prolonged oral administration.
This work was based on the study of an intra-articular delivery system constituted by a poloxamer gel vehiculating clodronate in chitosan nanoparticles.
This encapsulation has significantly improved the efficacy of the drug in a rat model of PTOA and provided supporting evidence to the utility of formulating IL-1 ra as a sustained release formulation for intra-articular delivery.
Here, we combined intra-articular delivery of gefitinib with an implanted customized collagen scaffold to substitute for lost meniscal tissue, as well as to promote meniscal regeneration and prevent osteoarthritis (OA) progression in a rabbit meniscectomy model.
After topical application of the optimized compound patch to only one knee joint in rabbit, intra-articular delivery of TEF and LOX on the application site was compared with that on the non-application site.
The aim of this work is to develop a compound transdermal patch containing teriflunomide (TEF) and lornoxicam (LOX) to transport these drugs across the skin with the isochronous permeation rates for RA therapy and investigate intra-articular delivery of TEF and LOX following transdermal patches applied topically.
In vivo, the intra-articular delivery of rAAV2/LacZ showed transduction of mostly synovium.
These data suggest that intra-articular delivery of μ-dHACM may have a therapeutic effect on OA development.
It has been speculated that intra-articular delivery of TGF-β1 would result in enhanced synthesis of new matrix [ 9].
