The issue that is presently in your hands is filled to the brim with high-quality orthopedic research, including 9 articles based on registry data.
31 43 The present findings highlight inconsistencies in harms-related reporting between published articles and trial registry summaries of psychotropic drugs, and indicate that clinical decisions regarding drug use may be based on substantially truncated evidence.
6 Furthermore, a recent study found that clinical study reports were more complete in their reporting of outcomes than published articles and trial registries combined.
The use of reporting thresholds in the reporting of treatment emergent adverse events in journal articles and trial registries is problematic as important, but rare, events such as suicidal thoughts, behaviour, and attempts usually fall below the threshold.
Objective To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, with respect to benefits and major harms.
Harms were generally poorly reported in journal articles and Lilly trial registry reports.
32 In conclusion, we found that clinical study reports contained extensive data on major harms that were not available in journal articles and in trial registry reports.
Conclusion Clinical study reports contained extensive data on major harms that were unavailable in journal articles and in trial registry reports.
Because of the use of reporting thresholds, data on between a median of 406 (range 177-645) and 166 (100-241) treatment emergent adverse events in the randomised phase per trial were not reported in journal articles and Lilly trial registry reports, respectively.
In each trial, a median of 406 (range 177-645) and 166 (100-241) treatment emergent adverse events (adverse events that emerged or worsened after study drug was started) in the randomised phase were not reported in journal articles and Lilly trial registry reports, respectively.
Microsoft has specific instructions on how to edit your registry in article No. 812930 in the Knowledge Base area at support.microsoft.com.microsoft.com
