A recent review pooling results of four NSAID trials indicated that NSAIDs were superior to placebo in improving spinal pain, peripheral arthritis, and function in AS patients over a 6-week period (Zochling et al. 2006a).
Subsets of CD4+ T cells with regulatory capacity, such as CD25+ regulatory T (Treg) cells and Th2 cells, have been identified, and recent observations suggest that in rheumatoid arthritis the function of these regulatory T cells is severely impaired.
A validated native language version for performance tests may not be a prerequisite, but since the validated and currently used performance test were quick and easy to perform, we refrained from introducing new instruments such as the Sequential occupational dexterity assessment (SODA) [ 30], and the Arthritis hand function test [ 31].
Our results highlight a paradoxical arthritis-regulatory function of exogenous TNFα.
There were also trends for improvements in self-efficacy towards managing arthritis-related functioning (P = 0.06), in self-efficacy towards physical activity (P = 0.07) and in symptoms of anxiety and depression (P = 0.08).
End-stage ankle arthritis impairs joint function and patients' mobility.
Moreover long immobilization has been correlated with high percentages of arthritis and decreased function rating between 50 80% [6, 15, 17].
PRO assessments included HRQoL, fatigue, physical function, arthritis pain and disease activity.
We included comorbidities that may impact physical function: arthritis, stroke, diabetes mellitus, chronic bronchitis, emphysema, asthma, myocardial infarction, congestive heart failure, and cancer (excluding skin cancer).
We analyzed the fraction of animals with arthritis as a function of time, by fitting time-response models to our data.
