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In isolated and perfused small bovine coronary arteries, administration of cathepsin L (200 ng/ml) markedly attenuated endothelium-dependent vasodilator responses to bradykinin or A23187 by 56.16 ± 9.58% and 68.95 ± 10.32%, respectively.
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Intra carotid artery administration of PACAP1 38 induces an ED50 (the dose of a drug that gives half-maximal response) response in dural arteries at ten times lower concentrations of PACAP1 38 than after i.v. infusion [52].
Balloon injury to rat carotid artery, administration of adenovirus, and neointimal quantification were performed as previously described 30.
Hepatic glucose uptake did not increase with peripheral GLP-1 administration but increased with either portal or hepatic artery administration, suggesting either a direct hepatic effect or hepatic GLP-1 receptors activating central signaling causing increased glucose uptake.
Ultrasound evidence exists that demonstrates the occurrence of arterial vasospasm in the brachial arteries following administration of 5-FU [ 11, 12].
In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml).
2) Increased blood flow in the hepatic artery during administration of ornithin-vasopressin suggests that the hepatic arterial buffer response was involved.
Vascular injury was induced by wire-insertion or ligation of the mouse femoral artery or administration of an atherogenic diet to apoE-deficient mice.
The procedure was performed through the femoral or radial artery after administration of unfractionated heparin (100 U/kg).
On the other hand, in a rat model of focal cerebral ischaemia induced by MCAo (middle cerebral artery occlusion), administration of mGluR1 antagonist LY367385 immediately after ischaemia appeared to show neuroprotective effects (Kohara et al., 2008; Murotomi et al., 2008, 2010).
A coronary artery angiography performed on the same day revealed no narrowing in the coronary artery, but the administration of ergotamine induced vasospasm in the artery.
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