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However, two elegant physiologic studies performed in septic shock patients have shown that arterial pressure changes induced by changing norepinephrine doses do not influence sublingual MFI across a large range of arterial pressures and norepinephrine doses [ 20, 21].
We assessed the adequacy of a prototype device (Nexfin-paediatric), designed for a paediatric population, for detecting rapid arterial pressure changes in children during cardiac surgery.
Drugs inducing not only QT prolongation but also positive and negative chronotropic effects, positive and negative systemic arterial pressure changes and ECG morphology alterations were useful to identify test system limitations during performance qualification.
The sensitivity analysis consisted in perturbing each parameter of the model and integrating the system of equations to see how the resulting arterial pressure changes with such perturbations.
Systolic arterial pressure changes followed respiratory flow (see Section 'Interactions between respiration and SAPV') both in supine and standing positions and even after selective autonomic blockade.
First, assessing its precise effects requires a direct measurement of cardiac output and cannot be based solely on the arterial pressure changes.
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Mean arterial pressure changed significantly in each group with a similar pattern without significant differences between the groups.
(b) The arterial pressure change associated with decreasing the dose of NE may be mostly due to the arterial vasoconstrictor (α-adrenergic) effect of NE.
Mean pulmonary arterial pressure changed inconsistently.> -wrap-foot> aWith respect to reference [ 19], values were derived from the calculation of mean values between 60 and 70 mm Hg for 65 mm Hg and between 80 and 90 mm Hg for 85 mm Hg.
These utilize different algorithms to relate changes in arterial pressure to changes in stroke volume and thus cardiac output [ 1, 2, 4, 8, 9, 11].
To elucidate mechanisms involved in arterial blood pressure changes after inhalation of CAPs and the potential involvement of peripheral vaso-constriction in observed increases in arterial blood pressure, we determined baroreceptor reflex sensitivity before and after exposure to CAPs or FA and performed additional experiments with α-adrenergic blockade.
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