Exact(56)
Since we had long-term prospective data, we then assessed the longitudinal pattern of ART exposure by examining ART adherence during the six-month period preceding each semi-annual follow-up visit throughout follow-up.
· Previous ART exposure; · Currently taking ART; · Previously assessed for ART eligibility; · Pregnant.
Exclusion criteria: · Previous ART exposure; · Currently taking ART; · Previously assessed for ART eligibility; · Pregnant.
Subjects were only allowed to have minimal ART exposure prior to study entry (no ART within 8 weeks prior to study entry, no more than 31 days of any ART within 6 months prior to study entry, and no more than one ART regimen on which they had experienced treatment failure).
These women first contributed person years to the non-ART group and, after ART exposure, contributed person years to the ART group.
Importantly, the US study included many children with mono/dual ART exposure, so the effect of age at initiation of combination ART in previously untreated children could not be assessed; these children also received combination ART with protease inhibitors or NNRTIs.
Limiting the multivariate analysis to those patients who started ART during TB treatment ( i.e. excluding the 133 who were already on ART at the time of TB diagnosis) did not substantially change the association between ART exposure and lower risk of death (HR 0.32, 95% CI 0.20 0.52), nor did limiting the analysis to males or females alone (HR 0.47, 95% CI 0.32 0.71 and HR 0.23, 95% CI 0.08 0.64).
Similar(4)
In these studies, the same individual may therefore contribute to pre- and post-ART exposure groups.
To our knowledge, this is the largest study to date of POPs exposure and infant growth, and it contains state-of-the-art exposure modeling.
This state-of-the-art exposure chamber is capable of providing controlled exposures to freshly generated diesel exhaust from a heavy-duty diesel engine.
Through the use of the established population based Border Air Quality Study cohort with state-of-the-art exposure modeling, we were able to efficiently evaluate the effects of proximity to traffic, ambient air pollution, and community noise on the risk of developing RA.
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