Current systems biology uses top-down and bottom-up approaches to arrive at complete and quantitative descriptions of particular systems of interest [ 5].
In order to arrive at complete transcripts, we re-predicted all transcripts with Genewise [ 51] using separate hidden Markov models of the first two exons and of the third exon.
To arrive at complete UTR sequences and further increase our confidence in these annotations, we required that PAS candidates could be connected to a stop codon in the same terminal exon via overlapping EST/cDNA alignments, using gene annotations based on RefSeq.
This is expected to bias the sequencing against GC-rich regions of the genome and is therefore not suitable for arriving at a complete Neandertal genome sequence.
Given the critical role of miRNAs in gene regulation, temporal and spatial control of the expression of individual MIR genes needs to be elucidated before arriving at a complete understanding of the gene networks mediated by miRNAs.
My most prescient recollection of that meeting with Utzon was his imaginative vision of what arriving at the completed Sydney Opera House would be like: the long climb up the Mayan steps into the vaulted concrete foyers and by degrees entering into the auditoriums, their colours coalescing as we focus on the stage curtain.
By continuing in this manner, one will, according to Fichte, finally arrive at a complete deduction of the a priori structure of ordinary experience or, what amount to the same thing, a complete inventory of the "original acts of the mind".
And what once appeared to be a regional quirk is increasingly viewed by scientists as something more: a near-perfect laboratory, arrived at by complete accident, for the study of human kinship.
By the study and sometimes forced exegesis of Aristotle and then Plato, culminating in Plato's dialogues Timaeus and Parmenides, of which they offered a variety of highly metaphysical interpretations totally unacceptable to Plato scholars, they believed it possible to arrive at a complete understanding of divine truth.
With consummate skill, Naipaul will introduce a character or a scene, leave it behind for 20 pages or so while he takes off in a different direction, return to it to add a few more brushstrokes, and then, somehow, after several such loops, arrive at the complete picture with the reader still at his side.
