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SPAG5 downregulation induced remarkable G2/M arrest; the proportion of G2/M cells increased from 11.858±0.880%too 24.439±2.815% (P=0.0264) without influencing other cell cycle phases.
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Down-regulation of NPM gene could arrest the cell cycle progression, an increase in the proportion of G0/G1 phase in knockdown groups.
Of the 84 hospitals with an MET, 24 provided adequate data to the ANZICS database to determine the number and rate of intensive care unit (ICU) admissions following an in-hospital cardiac arrest, and the proportion of ICU readmissions, one year before and one year after implementing the MET.
In our study, we demonstrated that Sorafenib induced cell cycle arrest by decreasing the proportion of cells in the S and M phase hindering the efficacy of cytarabine.
Specifically, it seems that loss of these marks on DNA damage mainly reflects DNA damage inducing G2/M arrest, thus reducing the proportion of mitotic cells, a cell-cycle phase where these PTMs are most abundant.
Get the proportions right.
At 16 Gy, cells of both sub-lines became arrested in G2 but the proportion was much lower than in HeLa cells.
Upon shifting to a defined arginine-deficient medium (AFM), growth arrest and reduction in the proportion of viable cells were observed.
Sorafenib induced G1-phase arrest and significantly decreased the proportion of cells in S phase when administrated alone or followed by 5-FU.
The loss of clonogenic potential following TTC5 KD was in large part due to induction of apoptosis, although a modest but statistically significant G1 arrest with reduction in the proportion of cells in S phase was also observed.
However, forced expression of BCL2 did not rescue the modest but significant G1 arrest and reduction of the proportion of cells in S phase, likely explaining why only a partial rescue was observed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com