The phrase "arrest cell differentiation" is correct and usable in written English.
It can be used in scientific or medical contexts, particularly when discussing processes that inhibit or stop the development of cells into specialized types.
Example: "The researchers discovered that the new drug could effectively arrest cell differentiation in cancer stem cells, preventing tumor growth."
Alternatives: "inhibit cell differentiation" or "suppress cell differentiation".
When PRAME is absent, the activation of the RAR pathway by retinoids will lead to proliferation arrest, cell differentiation and apoptosis [12].
p21Waf'1/CIP1 is a member of the Cip/Kip family of cyclin dependent kinase inhibitors that bind to and inhibit the cyclin dependent kinases, cyclinE/cdk2 and cyclinD/cdk4, which in turn prevents the phosphorylation of retinoblastoma protein (Rb) in order to induce cell cycle arrest, cell differentiation or senescence [1] [5].
These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo.
The over-expression of p53 in HT29 cells could well explain cell-cycle arrest, cell differentiation and the late induction of genotoxicity.
This could lead to alterations in gene expression effecting cell growth, cell cycle arrest, cell differentiation, and programmed cell death (apoptosis) that can be reconstituted by HDACi.
Calcitriol, the most active metabolite of vitamin D, elicits significant antiproliferative activity in breast cancer cells by several vitamin D receptor (VDR) mediated mechanisms including regulation of growth arrest, cell differentiation, migration, invasion and apoptosis [ 12- 14].
The higher levels of βIII Tubulin detected in the knockdown indicated that Msi1 arrests cell differentiation.
Tumor-suppressor genes regulate diverse cellular activities, including DNA damage repair, cell cycle arrest, cell proliferation, cell differentiation, migration, and apoptosis [ 14].
This induces a variety of responses including cell cycle arrest, cell death, differentiation and senescence, depending on the cell lines and inhibitors used [ 7, 8].
This growth inhibition was associated with G1 cell cycle arrest and cell differentiation.
This may also explain the direct linkage from the cell cycle arrest to cell differentiation by the C/EBPβ-p57 signaling, unlike the cGKII signal, as mentioned above.
