The aim of this study was to evaluate the feasibility of using novel autoantibody and cancer-related protein arrays to identify potential biomarkers for the early detection of esophageal adenocarcinoma in serum.
For using whole-genome tiling arrays to identify previously unknown transcriptional elements like small RNA and antisense RNA in prokaryotes, existing data analysis tools need to be tailored for prokaryotic genome architecture.
In this paper, we utilize DNA arrays to identify differential gene expression events induced by toxin exposure for the purpose of developing a reporter gene assay system compatible with insertion into a cell-based sensor platform.
Simultaneously, we used expression arrays to identify a pro-angiogenic gene profile in HBMVECs stimulated by VEGF.
We first tested whether, despite these potential limitations, we could use the arrays to identify known specific RNA-protein interactions.
We assessed the lineage specification using previously published markers [21] (Figure 3A, right-hand panels) and then used methylation arrays to identify genes that became hypomethylated during differentiation.
Next, we used conventional sequencing and Affymetrix P. aeruginosa Genome arrays to identify genomic regions present in library populations before and after selection.
Previously, we described an approach for screening high-density peptide arrays to identify specific peptide sequences that anchor enzymes to surfaces and modulate their activity [13].
To explore this issue we used Nuclear Receptor PamChip® Arrays to identify differences in coregulator recruitment between WY14643 and C22 6.
We used methylation arrays to identify genes hypermethylated in CD34+ somatic stem cell progenitors (Figure S7) compared with peripheral blood lymphocytes and neutrophils, two types of adult primary cells derived from the CD34+ hematopoietic progenitors.
In the work described here, we use chromatin immunoprecipation (ChIP) and whole genome, high density tiling arrays to identify the sequences bound by Ubx and Hth in both the T3 leg and haltere imaginal discs (Figure 1).
