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While the isolation was selective, a standard TAR cloning technique does not allow to recover a significant fraction of alphoid DNA arrays that does not contain ARS.
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So he devised all sorts of interesting arrays that didn't play the 12 tones of the octave in any conventional way.
The affected samples were reevaluated on replacement arrays that did not repeat the problem.
The procedure removes the systematic differences between arrays that do not represent true biological variation.
However, many bacteria contain soluble cytoplasmic chemoreceptor arrays that do not associate with any membrane [e.g., Vibrio cholerae].
All arrays that did not satisfy one or both of the quality thresholds were removed from the database.
Chip pseudo-images were produced to assess artifacts on arrays that didn't pass the preceding quality control tests.
17 additional tandem arrays that did not contain genes were categorized as megasatellites because they are made up of repeat units that contain interspersed TEs.
Cuadros et al. identified a poor prognostic signature related to proliferation using gene-expression arrays that did not differ between AITL and PTCL-NOS, although they did not study the AITL cases alone.
Importantly, when performing focused aCGH with specialized arrays that do not cover the entire genome, or comprise probes with a disproportioned focus on specific genomic regions, even CNAs that affect a minor part of the genome can introduce a significant correlation between copy number and intensity, and can result in misinterpretations of how a given ratio level relate to copy number.
However, this was ruled out by the discovery of human dicentric chromosomes containing α-satellite DNA arrays that do not nucleate kinetochore formation (Earnshaw and Migeon, 1985; Earnshaw et al., 1989) and functional neocentromeres lacking α-satellite sequences (Voullaire et al., 1993).
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