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Some computer systems used in genomic research, for example, use programmable arrays that allow the machines to be customized quickly each time they search for a particular DNA sequence among millions of possible combinations.
This paper considers the construction of D-optimal two-level orthogonal arrays that allow for the joint estimation of all main effects and a specified set of two-factor interactions.
One advance is the Affymetrix Human Exon 1.0 ST arrays that allow a high-throughput, genome-wide approach to analyze both differential gene expression and alternative splicing on a single chip.
These are four-plex arrays that allow for the examination of mRNA expression of ~20,000 genes from four samples.
For species like the chicken where the whole genome has been sequenced it is possible to construct tailored whole genome arrays that allow comprehensive gene expression studies.
To verify that germline expression of CPS-2B is sufficient to mediate the csp-2 function, we expressed a GFP CSP-2B fusion under the control of the pie-1 promoter (P pie-1GFP CSP-2BB) in complex transgene arrays that allow expression ofusionsgenes in the germline 20.
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The first of these was the development of genome-wide arrays that allowed simultaneous screening of the entire human genome in thousands of samples for novel AD loci.
To analyze the data, we developed a novel algorithm for the analysis of two-color arrays that allows for a statistically robust identification of candidate spliced genes in absence of a prior hypothesis about the contributing isoforms.
The vessel is fitted with an array of 3D, high-definition stereoscopic cameras and a vast lighting array, that allowed him to film this deep, dark spot.
The PR, operating at 13.8 GHz, is a 128-element active phased array that allows fast and sophisticated cross-track scanning over a swath width of 215 km with a cross-range spatial resolution of about 4.3 km.
We designed a bespoke Roche Nimblegen 12x135K CGH array that allowed for the simultaneous targeted interrogation of all coding exons of 17 LGMD genes, with additional widely-spaced backbone probes providing coverage across the whole genome.
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