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Similar interactions also occur to stabilize interstrand association, as seen when arrays containing exclusively H2A-E64C are mixed with arrays containing only H4 V21C.
The Affymetrix SNP arrays containing only 25-mers, however, showed signal-to-noise ratios which were only slightly lower than the BAC array platform after data normalization using the CNAG package.
The detection of alternative splicing using arrays containing only exon probes is based on the idea that a discrete set of exons, some of which are skipped in the event of alternative splicing, constitute the final mRNA.
Alternatively, using RPP one could readily generate a short list of SFP-bearing probe sets using datasets derived just from parental genotypes and then develop smaller, less expensive arrays containing only the probe sets that contain SFPs, reducing the cost per mapped SFP accordingly.
For example, using a common reference sample in combination with a test sample of type A and type B on one array allows a direct comparison of the relative gene expression levels in both test samples, without having to compare relative expression values from two or more dual-target arrays containing only a reference and one of the test samples.
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In addition, our arrays contained only homologs of a 90-kda heat shock protein (HSP90) (AOSF1451) and a 97 kDa heat shock protein (CAOO2018).
Since our arrays contained only a subset of the genome with a non-random distribution of sex-biased genes, we used the gDNA spots as controls for normalization.
Firstly, the arrays contain only a small proportion of the low MAF variants that actually exist; this is due to the array design being motivated by the detection of common susceptibility variants.
In 2009, Chen et al. [ 18] identified a 38-miRNA signature by PCR array (containing only 156 miRNAs), which could discriminate ICC from normal cholangiocyte.
Additional File 1 compares the MCR extracted spectra from a spotted array containing only Cy5-dCTP in the spots and a second spotted array containing only Cy5-cDNA in the spots showing the effect the molecule Cy5 is attached to can have on the emission maxima of Cy5.
A validation array containing only the ten lysate pools from the three million clone library selected as reacting significantly different to the tumor vs. control sera, and the five negative control pools was printed and tested.
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