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Pearson correlation coefficients between genes on the array were computed using Octave (full cohort: n = 2,145, cardiac cohort: n = 239).
Then, the mean values for all IgG's on the array were computed for each individual subject.
The fold-change of genes with more than one probeset on the array were computed as the average fold-change between all corresponding pobesets.
The GNUSE values for every array were computed with the package fRMA (McCall et al., 2010) and relevant packages with fRMA vectors available in Bioconductor.
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Using a similar method to compute Laddr, Zaddr, which is the position of bit node (x, y) in the one-dimensional array, is computed as follows: Figure 9 One-dimensional address generation for parallelization (bit node).
The reference position of the antenna array was computed using the outputs of SPAN™ LCI unit, which provides ultra-tight GNSS-INS solution with accuracy of the order of at least a few decimetres.
The probability that the intersection of these two groups would include 23 probes given a total of 12,626 probes on the HG-U95Av2 array was computed by the hypergeometric distribution using the R statistical programming language (http://www.R-project.org) and the p-value (p = 0.005) was computed.
The energy distribution within the data array
The signal for each spot on the reference array is computed as the median of the corresponding spots in all arrays.
The RLE for every spot in the array is computed as the difference between that spot and the same spot in the reference array.
Percent present for each array was computed as the number of probesets called Present out of the total number of probesets.
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