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The person briefed on the case described it as a "lone-wolf scenario" and said that Mr. Pimentel had been considering a possible array of targets that included government employees, lawmakers and military personnel returning from overseas service.
The secretion machinery of yeasts is a multi-step process and each step is directed and regulated by several proteins, providing a vast array of targets that can be manipulated to enhance heterologous protein secretion.
The transcription factors produced by PERK, IRE1, and other UPR signaling pathways collaborate to control behavior, metabolism, and ultimately cell fate in response to ER stress by inducing a wide array of targets that include protein folding chaperones such as ERdj4 [8] and additional transcriptional activators such as Chop [3].
Because the array of targets that respond to changes in redox status fluctuate during the cell cycle, ROS levels affect cell fate variably.
A variety of transcription factors activated during UPR collaborate to induce the expression of a wide array of targets that include ER chaperones and genes involved in ERAD to enhance the protein folding capacity of the cell and to decrease the unfolded protein load of the ER [ 5].
Similar(55)
Moreover, even when they identify one or more 2s, most people usually fail to detect patterns of targets that may be embedded in the array.
In the past 2 decades, expansion in the knowledge of molecular medicine and genomics has revealed an array of new molecular targets that are being harnessed for the design of new therapies in oncology.
In addition, target identification has produced a wide array of viral and cellular targets that inhibit HIV-1 replication upon silencing.
If that works out, she'll begin adapting the particles for an array of targets.
The ubiquitin system or 'ubiquitome' has been compared with the well-characterised 'kinome' and has spurred an entire array of novel inhibitors against molecular targets that manipulate ubiquitin and ubiquitin-like molecules.
Trump is finding that the anger of this movement can be harnessed to attack a broader array of targets than just Washington politicians.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com