Beyond normal aging, there are a wide array of pathologies (e.g. macular degeneration, retinitis pigmentosa, and cataracts) that can further diminish or entirely eliminate a person's ability to see the world.
Our previous work explored the activity of serotonin in an array of pathologies, particularly those in which epidemiological data suggests gender differences [ 7].
Understanding the molecular pathways that link tumor biology to the staggering array of pathologies and genes is of paramount scientific and medical importance.
Therefore, considerable compositional information can be gleaned from a single, small-scale sample preparation, a feature of ALSA which has been widely exploited for a diverse array of pathologies [ 28- 30].
Anp32b-deficient mice demonstrated a strain-dependent penetrance of perinatal lethality with surviving mice in a genetically mixed background showing growth defects, premature aging, and a wide array of pathologies 101.
Low systemic GSH levels have also been implicated in a wide array of pathologies such as cardiovascular diseases [26], neurodegenerative diseases [30], diabetes [41], and cancer [45], in addition to developmental disorders such as congenital heart defects [19].
This single test was the key to the finding that patients with a wide array of clinical pathology in multiple organ systems, in fact shared a common autoimmune etiology [ 3].
Apolipoprotein genes have been associated with GWAS significance to a remarkable array of age-related pathologies including chronic renal disease, cardiovascular disease, inflammation, metabolic disease, hepatic dysfunction, alzheimer's, dementia, and cognitive decline (Melegh et al., 2012; Schmidt et al., 2012; Wasser et al., 2012; Imes & Austin, 2013; Tosto & Reitz, 2013).
These diseases are associated with a complex array of cellular and molecular pathologies.
In human pathology, an array of colorectal polypoid lesions, considered to be prolapse-related, has been described, including the redundant prolapsing mucosal folds seen in diverticular disease (Kelly, 1991), stomas, cap polyposis (Campbell et al., 1993), angiogenic polypoid proliferation (Abrahams et al., 2001), and cloacogenic polyps (Singh et al., 2007).
Senescent cells accumulate with age, are found in increased numbers at sites of pathologies associated with aging, and secrete an array of inflammatory factors, chemokines, matrix metalloproteinases, and growth factors designated the senescence-associated secretory phenotype (SASP).
