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The complexity of the disorder, plus the sheer variation in how it can manifest suggest a complex condition with an array of modifying variables.
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The expanding array of modified fats and oils has been designed to have greater shelf stability due to an increase in monounsaturated fat and enhanced health benefits due to a reduction in trans fat.
The custom CMOS camera is a linear array of modified active pixel sensors.
We have designed a multi-coloured bead array which includes the possibility of modifying the surface properties of the microparticles, which offer excellent properties for covalent attachment of biomolecules such as peptides, oligonucleotides, proteins, etc.
Another important aspect in Exon Array projects is the ease of modifying the filtering conditions.
In this work, four helical resonators are distributed in a 2×2 array by modifying the upper part of the conventional reactive ion etching type LCD etcher.
In this way, SPOT arrays containing hundreds of modified peptides have been used to profile the specificity of a range of sequence specific methyllysine reader domains, including the CDs of HP1β and HP1γ, the PHD finger of the chromatin remodeler ATRX, and the PWWP domain of a DNA methyltransferase, among others.
Other reported approaches have used open arrays of wells modified with capture antibodies either on the bottoms of the wells or on the planar surfaces between wells to bind proteins released from cells over hours to days of incubation (see Figure 1B, as well as Figure S1 in the Supporting Information).
To further optimise Leishmania CRK3 potency, we synthesised an array of analogues by modifying the phenyl ring (Scheme 3).
Fortunately, as we describe in section 'Inexact pattern matching', suffix arrays defined under this kind of modified lexical ordering can be constructed in essentially the same way as conventional suffix arrays [ 27].
In addition to its directs effects on components of chromatin, PARP-1 may also modulate the localization and activity of a broad array of histone-modifying and nucleosome remodeling enzymes.
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