In animal models, enzastaurin showed antitumour and antiangiogenic activity in a wide array of human tumours, including non-small cell lung (NSCL), colon, renal cell and hepatocellular carcinomas (Keyes et al, 2002; Liu et al, 2004).
Indeed, a growing body of evidence suggests that the sensitivity of an array of human tumours to mTOR inhibition is, indeed, associated with the abnormal activation of the PI3K-Akt-mTOR pathway and/or with an altered expression of cell cycle regulatory or anti-apoptotic proteins [ 61– 63].
Large-scale sequencing of human tumours has uncovered a vast array of genomic alterations.
More recently, genetic analyses of human tumours have indicated that NRF2 may conversely be oncogenic and cause resistance to chemotherapy.
Tamoxifen work showed that lab grown cultures of human tumour cells will respond to drugs that are effective in patients.
Hahn, W. C. et al. Creation of human tumour cells with defined genetic elements.
OPN has been detected in a growing number of human tumour types, including lung, breast, prostate, gastric, oesophageal, ovarian and glioma, by immunohistochemistry on tumour tissue sections, quantification of OPN RNA from tumour tissue or in expression array studies from tumour tissues (reviews: Furger et al, 2001; Tuck and Chambers, 2001).
However, several studies have shown that enzastaurin exhibits direct growth inhibiting effects on a wide array of cultured human tumour cells (Graff et al, 2005; Oberschmidt et al, 2005; Querfeld et al, 2006; Rizvi et al, 2006; Podar et al, 2007; Spalding et al, 2007; Lee et al, 2008).
The aim of this study was to perform a systematic review and a meta-analysis of the correlation between MGMT IHC and MSP in a large array of human brain and non-brain systemic tumours.
The development and implementation of high-throughput array technologies to primary human tumours is changing the scientific and clinical paradigm, providing novel predictive and therapeutic targets for the cancer patient.
