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They validated the candidates via immunohistochemistry and tissue array of human tumor samples.
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Data from array analysis of human tumors and mouse models point to different genetic alterations in the initiation and progression phases of meningiomas.
For example, a threshold RIN value of 7.8 has been recently proposed for optimal RNA reliability for analysis of human tumor samples on Affymetrix GeneChip arrays, where reliability was defined as a 3'/5' Gapdh ratio threshold ≤ 1.25 [ 10].
Finally, we examined whether RNA obtained from needle core biopsies of human tumor xenografts, amplified and indirectly labeled, would generate representative array profiles compared to larger excisional biopsy material.
Tumor center researchers have access to an unusually diverse range of human tumor cultures.
A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines.
More recently commercially available high-density oligonucleotide based SNP arrays have been employed in whole-genome copy number analyses of human tumors.
Vaira, V. et al. Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors.
Examination of an array of human brain tumors consistently showed abundant cytoplasmic, ER-associated c-Fos expression.
Though several studies have demonstrated elevated levels of multiple IAPs in an array of human cancers as well as tumor models, a clinical correlation could not be established for many of them.
We investigated the functional mechanisms of MORAB-003 (farletuzumab), a humanized mAb against FRα, in ovarian cancer models.We first examined FRα expression in an array of human ovarian cancer cell lines and then assessed the in vivo effect of MORAB-003 on tumor growth and progression in several orthotopic mouse models of ovarian cancer derived from these cell lines.
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