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This acquired general statement is underpinned at molecular level by a complex array of genetic alterations that affect cell processes and determine the self-progression of the neoplastic disease and its response to therapy [ 6, 7].
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> -wrap-foot>> -wrap-foot>> -wrap-foft> Summary of genetic alterations detected by array CGH involving genes of known relevance to GBM progression Immunohistochemical staining was semi-quantitatively determined as 0/no expression, +/low expression, ++/moderate expression or +++/high expression.
Figure 1 shows the cluster dendrogram for the 24 tumours of the five patients based on the similarity of genetic alterations detected by array-CGH.
Lage J, Leamon J, Pejovic T, Hamann S, Lacey M, Dillon D, Segraves R, Vossbrinck B, González A, Pinkel D, Albertson DG, Costa J, Lizardi PM. (2003) Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH.
Mullighan et al. [105] performed a genome-wide analysis of genetic alterations in 242 paediatric acute lymphoblastic leukaemias (ALL) using 100K and 250K SNP arrays.
But these types of genetic alterations are not inherited.
Shimmer: detection of genetic alterations in tumors using next-generation sequence data.
Different combinations of genetic alterations cause lung tumours with distinct molecular and histopathological features.
Mullighan, C.G. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukemia.
Curtin, J.A. et al. Distinct sets of genetic alterations in melanoma.
Mullighan, C. G. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
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