Squamous metaplasia associated with expression of the full array of terminal differentiation markers of the suprabasal layers of the epidermis was found only in adenosquamous carcinomas (Fig. 6a,6b,6c,6d,6e,6f,6g,6h,6i).
Therefore, miRNA molecules can modulate a wide array of growth and differentiation processes in cancer [ 4].
To study MSC differentiation, an array of in vitro assays has been developed.
miRs control a wide array of biological processes, including cell differentiation, proliferation, and apoptosis.
They play a critical role in a wide array of biological processes that include differentiation, viability, inflammation and catabolism.
All data presented above point out β-catenin as a major sensor of an array of signals and imply that differentiation defects in tissue homeostasis are likely to underlie tumorigenesis because of inactivation of the APC/ β-catenin signalling pathway.
Epigenetic inactivation of such transcription factors may affect multiple downstream genes, causing aberrant alteration of signalling pathways involved in a wide array of cellular functions, including growth, differentiation and apoptosis.
A wide array of signals regulate keratinocyte terminal differentiation [ 8– 12] and mathematical methods have been used to identify dysregulated feedback mechanisms which contribute to a variety of skin pathologies [ 52– 52].
cluster-of-differentiation 14 subtypes.
Whereas a single microphone allows only the total sound level to be estimated at the measurement location, an array permits differentiation between the contributions of distinct components.
