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To maintain genomic integrity and prevent cancer in the face of these potentially mutagenic events, cells have evolved a sophisticated array of damage sensors, signaling molecules, and repair functions.
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The human 3-methyladenine DNA glycosylase (AAG, MPG) removes a diverse array of damaged purines via a nucleotide-flipping mechanism.
The National Weather Service was also reporting wide array of property damage along California's most northern coast.
Appropriately designed in vitro studies and in vivo placebo controlled trials with dose responses using a complementary array of DNA damage biomarkers are required to define recommended dietary allowances for genomic stability.
ROSs can directly induce a wide array of DNA damage including base oxidation, sugar fragmentation and single strand DNA breaks.
The p53 protein is a principal mediator of growth arrest, apoptosis, and senescence in response to an array of cellular damage [ 1- 3].
Tobacco smoke is another external source of DNA damage, but it leads to a more complex array of DNA damaging agents and lesions than UV does [ 5].
NOx can cause a wide array of environmental damage--including smog, acid rain, and even degradation of water quality--as well as endangering the health of human lung tissue.
Since trisomies produce adverse effects relatively late in development or even postnatally, they are an important component of the array of genetic damages that might be caused by environmental agents.
When competing firms make bets on a wide array of strategies, the damage of bad bets are contained.
In the future, clinical trials with a defined wider array of complementary DNA damage end-points would be necessary.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com