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The team also put the cells in mice, where they turned into a wide array of cell types.
During hepatogenesis, complex developmental processes must generate an array of cell types that are spatially arranged to generate a hepatic architecture that is essential to support liver function.
Tolerance necessitates modulating a diverse array of cell types that recognize and respond to alloantigens, including antigen presenting cells and T lymphocytes.
Expression changes of selected proteins were verified by qPCR, western blot and/or immunofluorescence analyses in a wider array of cell types.
Building the human CNS requires the precise orchestration and coordination of myriad molecular and cellular processes across a staggering array of cell types and over a long period of time.
IL-17 is produced primarily by TH17 subset T lymphocytes, while IL-17 receptors are found in a broad array of cell types including fibroblasts and myofibroblasts [30], [31], [32].
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It may be that in man the complex array of septins and septin isoforms provides an array of cell type and context-specific spatial cues that similarly organise the spatial arrangement of other proteins, potentially in a highly regulatable manner.
Despite their ubiquitous expression in the nuclei of most cells, mutations in lamin genes cause a puzzlingly wide array of cell type-specific and subcellular-specific diseases in humans (Capell and Collins, 2006).
Because microparticles expose an array of cell-type-specific adhesion receptors, a direct interaction is likely.
Finally, this study has broad implications for development and disease because CENP-F loss of function affects a diverse array of cell-type-specific activities in other organs.
Conversely, avoiding unusual MT arrays may contribute to the conservation of major somatic isoform CTTs, which need to function in "normal" MT arrays across a diversity of cell types.
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