They consist in complex arrays of binding sites with defined specificities but susceptible of rearrangements without loss of function.
It seems probable that a PRE is more likely to be determined by the presence of multiple binding sites for an array of DNA-binding proteins, and that Pho binding may involve cooperative interactions with some combination of other DNA binding factors (Kassis and Brown 2013).
Given Hox homeodomains bind a wider array of DNA binding sites in vitro than are regulated by the full-length protein in vivo, regions outside the homeodomain must aid DNA site selection.
Analysis of the salm pouch-specific regulatory element revealed a tandem array of Ubx binding sites suggesting that Ubx multimerisation might obviate the requirement for Hox cofactor binding at specific target genes [21].
A key feature of HSP function is the ability to interact with a broad array of protein binding partners as a means to potentiate downstream response pathways or facilitate protein folding.
Stress granules contain translation initiation components and a diverse array of mRNA binding proteins, but the exact composition can vary depending upon the stress [5] [12].
This seems at odds with previous observations that the gypsy transposable element, which harbors a short array of SU HW) binding motifs, can target flanking DNA to the nuclear periphery in a SU HW) – dependent manner [43].
Nevertheless, it has been shown, that the array of nuclear binding partners significantly differs from cytosolic interactions [ 95].
