Complex structures of microsatellite arrays may play a role for the generation of minisatellites.
One approach for following up replicated findings from a GWAS would be to determine all genetic variation within the locus, especially rarer variants not currently included on GWAS SNP arrays, as they may play an important role in the etiology of the disease [13].
Some genes that showed expression variation on our array may not play an important role in the regulation of reproductive diapause itself, but instead may exhibit pleiotropic effects on life-history traits associated with diapause.
The NCAM1 minigene experiments together with the iCLIP and exon array analyses suggest SAFB1 may play an important role in regulating the organisation of the cytoskeleton, neuronal development and synaptic function.
Several review articles (Schilter et al., 2005; JECFA, 2008; Mally and Dekant, 2009) document a complex array of epigenetic mechanisms that may play critical roles in the development of kidney tumors and DNA adducts in rodents treated with OTA.
This transcript encodes a putative ribonucleoprotein with a distinctive array of zinc finger domains that may play an important role in embryonic development and neurogenesis, as reported for the amphibian makorin-2 [ 47].
The array results also indicate that Nub-PD may play a role in regulation of stress responses, either directly or indirectly, but this assumption needs to be further validated.
Moreover, only the apparently most relevant chromatin modifications have been studied so far but a much larger array of additional modifications are possible and may play an essential role in SM gene silencing and activation (Kouzarides 2007).
This specialized CGH array identified the chromosomal regions whose structural alteration may play critical roles in lung tumorigenesis.
Such factors seem unlikely in the case of the 65A array, in which well-conserved genes and highly labile genes are interspersed together, but may play a role in the evolution of the 44C array.
