Estimates for lifetime costs of wave energy arrays are difficult to obtain due to the uncertainty surrounding weather windows and failure rates for wave energy converters (WECs).
Importantly, the proposed concept of measurement could allow multiple analyses of analytes at nano-scale array, which is difficult to be analyzed by conventional fluorescence based method.
Without quality controls, for example by adding a control probe labeled with the same fluorophore as the target in the gel array, it is difficult to deconvolute these two processes.
As the Infinium 450k provides an estimate of the mean methylation status of the DNA hybridized to the array, it is difficult to say if only the extra copy of HSA21 is aberrantly methylated or if DNA methylation changes affect all the 3 copies of HSA21.
However at the small scale necessary for such testing, particularly when modeling rooftop arrays, it is difficult to create aeroelastic models that can accurately capture the structural response.
However, as the LTR only has 4 GR binding sites (∼800 1200 total in array) [37], it is difficult to utilize this interaction to track factor recruitment at the earliest stages of activation.
This limitation comes from differences in hybridization efficiency, as well as differences in cross-hybridization background among millions of array probes and is difficult to account for.
But there have been other indications of false positives from tiling arrays, and it is difficult to escape the conclusion that the non-coding RNA universe may turn out to be substantially smaller than earlier analyses suggest.
