Sentence examples for arrangement of binding from inspiring English sources
By taking into account the spatial arrangement of binding sites on a target protein, high-affinity multivalent ligands that geometrically complement their target can be designed and synthesized.
Such a protein can be locked in a conformation that is a poor representation of an actual spatial arrangement of binding site amino acid residues upon ligand binding [61], making it a poor candidate for target based virtual screening studies.
A candidate for such a factor is the promoter architecture, which includes such things as the number and position of nucleosomes, the arrangement of binding sites, and the overall spacing of elements throughout the promoter.
Here, we combine DNA sequence analysis and genome-wide expression data to discern the constraints on the arrangement of binding sites for transcription factors involved in regulating the synthesis of sulfur-containing amino acids in the yeast Saccharomyces cerevisiae.
This arrangement of binding sites likely enables Norrin to form a ternary complex.
Presumably, the overall 'A'-shaped RRE topology (Fang et al., 2013) and arrangement of binding sites dictates the positioning of newly recruited subunits.
We expect pairwise interactions between TFs on the DNA to require particular arrangements of binding sites.
Tridentate coordination in [Ni{L1}(H2O)(NO3)]NO3 supports formation of two chelates involving donors of two isoxazolidine and of pyridyl groups, with a facial arrangement of the binding sites around octahedral Ni ions.
The model gives new answers to old questions on the GPCR 3D structure, such as on the orientation and arrangement of the binding helices, their interaxial distances, radial orientations and relative heights.
While members of this cluster could be separated quite well from non-binders in receptor conformers displaying the right arrangement of the binding cavity, these 20 molecules were dumped at the rank bottom in all the other pocket variants.
However, the majority of known VDREs show a DR3-type structure comprising a directly repeated arrangement of hexameric binding sites with 3 spacing nucleotides [22].
