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The phrase "around a significant" is correct and usable in written English.
It can be used when discussing a topic or event that is related to or involves something of importance or consequence.
Example: "The discussion revolved around a significant change in policy that would affect all employees."
Alternatives: "concerning a major" or "regarding an important".
Exact(12)
There has been a 5% rise in sales in the past two years, turning around a significant decline in previous years.
McDowell was masterful alongside Dubuisson and turned around a significant deficit in the singles Rory McIlroy 8/10 Played 5 Won 2 Halved 2 Lost 1 Emphatic victory over Fowler to set the tone for Europe's Sunday.
Facts and figures simply aren't meaningful enough to rally employees and stakeholders around a significant change.
Another oddity of the Solar System is the absence of close-in super-Earths, which are found around a significant fraction (~50%) of main sequence stars.
He has spoken of not sending a team out to earn a draw, but that too can be acknowledged as part of the verbal sparring around a significant match.
We found 489 genes with an annotated function, among which 92 were localized within a QTL, and 91 were located in a 10-kb zone around a significant marker (Additional file 12: Table S4).
Similar(48)
But Petraeus, 60, is hardly the first high-profile figure to admit to fooling around on a significant other.
This revised classification algorithm identified a total of 98,691 segments from the set of 105,615 (around 93%), a significant improvement on the 82% of the initial extraction/classification algorithm.
In the present study, on the basis of the neck:bulb diameter recorded in open caveolae (around 1∶2), a significant proportion of caveolae recorded in the closed state in control cells (85% of the total) should represent true closed vesicles.
The figure floating around suggests that a significant amount of pension-fund income in Britain each year comes from BP.
Analysis points to failures in the health system during the critical time around delivery as a significant contributing factor to these unnecessary deaths.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com