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At younger ages heavy smoking is associated with around a fourfold to fivefold increased risk of prostate cancer then the HRs decrease with advancing age.
At the mean age, there was around a fourfold increased risk of intracranial bleed associated with new use of anticoagulants in men (adjusted hazard ratio 3.99, 95% confidence interval 1.86 to 8.55) and in women (3.62, 1.25 to 10.49).
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The Greenland ice sheet has recently shed around 200 gigatonnes of ice a year, a fourfold increase on a decade ago.
The TMD, on the other hand, has a fourfold axis of symmetry centred around the ion channel.
A fourfold population increase is a sobering prospect.
That's almost a fourfold increase in four years.
The move triggered a fourfold increase in ambulance call-outs.
Governments around the world must act to ensure people can make healthier food choices, the World Health Organisation has said in a report (pdf) revealing a fourfold increase in global diabetes cases since 1980.
Blake was hard on single vision: Now I a fourfold vision see And a fourfold vision is given to me; Tis fourfold in my supreme delight And threefold in soft Beulahs night And twofold Always.
That amounts to a fourfold increase in a decade.
My corner, too, just lost a long-established dry cleaner, to a fourfold increase in rent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com