The first similarity is the aromatic moiety that modifies the 5-position of the central pyrimidine ring, which corresponds to the 2-methoxyphenoxy group in bosentan.
Herein a bulge binding agent with novel wedge-shape topology of the aromatic moiety was designed and synthesized.
Typical CYP2D6 substrates generally contain a basic nitrogen atom and an aromatic moiety adjacent to the site of metabolism.
In all three structures, the aromatic moiety of the different ligands is bound in a hydrophobic pocket formed by the side chains of Val44, Val48, Trp47, Val51, Val52, Phe71, Cys73, Ile108, Phe111, Trp138, Leu160 and Ala164.
These observations indicate that the incorporation of aromatic moiety in side chain is a promising strategy to obtain stable blue-light-emitting polyfluorenes with enhanced efficiency.
Due to most drugs possessing hydrophobic phenyl-like structures, aromatic moiety could provide high drug-loading capacity and stability in drug delivery systems.
The size and shape of the aromatic moiety was varied, with the final variation introducing two carbonyl groups, yielding a substituted anthraquinone.
Wittig reaction to introduce aromatic moiety in 10 and chemoselective anomeric oxidation of 13 were used as key reactions in our synthesis.
Blue thermally activated delayed fluorescent (TADF) emitters were developed by linking a donor moiety to a triazine core via the ortho-position of an aromatic moiety.
The molecules consist of an isoxazole that pre-organizes a planar aromatic moiety and a simple amide and/or lexitropsin-oligopeptide.
They illustrate the transformation of PS into PO, the splitting between the phosphorous part and the aromatic moiety and the transfer of methyl or methoxy groups.
