This does not address the determination of ARM risk for individuals for whom mild to moderate retinal findings are present.
Druse proteins involved with inflammation and innate immunity (e.g., amyloid-β, immunoglobulin light chains, factor X, C3, C5b-9 complex) have received particular attention because sequence variants in several complement proteins are associated with increased ARM risk [13], [14], [15], [16].
The relationship between skin tone and ARM risk was not statistically significant.
The number of questionnaires returned were based on the assumed control arm risk.
To determine the proportion of people achieving abstinence by trial arm, risk ratios (RRs) will be calculated with corresponding 95% CIs.
In multivariate modeling (Table 2), patients in the AS+AQ and AS+SP arms had significantly less risk of having malaria episodes than patients in the AL arm; risk ratio [RR] = 0.84 (P = 0.002) and RR = 0.80 (P = 0.001), respectively.
In the PRIMA trial, the most frequent toxicities reported were grades 2 4 infection, occurring in 39% patients assigned to the MR arm, and in 24% on the observation arm (risk ratio 1.62; 95% CI: 1.35 1.96; P<0.0001.35 1.96
A high probability of risk-related treatment efficacy (decrease in log-odds mortality with increased control arm risk) was identified by metaregression in the low dose trials (n = 9, slope coefficient -0.49 -1.14, 0.27); P = 92.2%).
Bayesian meta-regression [ 21] was used to determine the relation between log odds mortality and (i) average patient age and (ii) control-arm risk, as log-odds mortality [ 17, 24].
