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Cntnap2 KO and wild-type mice were tested on a 4/8 radial arm water maze for 14 consecutive days.
After restraint ended, rats were tested on a radial arm water maze (RAWM) for 2-d to assess spatial learning and memory.
These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Aβ load.
Tg2576 mice exhibit impaired memory retention and memory acquisition by 6 and 12 months of age, respectively, when tested by hidden platform or by a radial arm water maze (RAWM) test [14].
The 2-day radial arm water maze has been previously described in detail [ 19].
The 2-day radial arm water maze protocol was carried out as previously published [ 15].
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We found that EHT administration protected animals from Aβ-induced cognitive impairments in both a radial-arm water maze and contextual fear conditioning task.
They compared the animals' ability to negotiate a radial-arm water maze, a standard test of cognitive ability, with that of regular J20 mice and of normal mice at 4, 9, and 14 months of age.
Aged Ts65Dn mice exhibited impaired hippocampal-dependent spatial learning and memory in the RAWM (radial-arm water maze) and a marked increase in levels of the lectican versican V2 in stratum oriens that correlated with the number of errors made in the final RAWM block.
Interestingly, in the eight-arm water maze task at 18 months of age, the Dnmt1+/+ mice appeared to remember the task, i.e., they could find the escape platform quickly, whereas the Dnmt1+/− mice did not remember this (note the significant difference in the performance by these two groups on the first day of training).
Cook Inlet, the long arm of water that reaches toward Anchorage from the Gulf of Alaska, is one of the busiest and fastest-developing regions in the state.
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