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The equilibrium positions of the dislocations have been determined and the two configurations where the arm orientations of the dipole are normal or inclined to the interfaces have been discussed versus the nanostructure dimensions and lattice mismatch.
Our sharply defined target zone implies a restrictive geometrical constraint on myosin head binding that is contradicted by the highly variable shape of strong binding cross-bridges, in particular their widely varying azimuthal lever arm orientations.
For cross-bridges whose lever arm orientations were angled toward the rigor configuration, we used an atomic model adapted from the Holmes et al. rigor acto/S1 complex [5] (available at ftp://149.217.48.3/pub/holmes).
With the exception of one Type 1 weak binding cross-bridge, a possible post rigor conformation, all the weak binding forms on actin subunits F K display a narrow range of axial and azimuthal lever arm orientations when aligned to the MD (Figs. 5B, 8A).
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One weak binding class, visible in panels W and Q in Figure 1, had a lever arm orientation toward rigor.
The short arm/long arm orientation of each linkage group could be established based on the positions of fosmid FISH analysis.
The lever arm orientation of A-states can be either "up" in a pre-working-stroke position or "down" in a post-working-stroke position; R-states are lever-arm-down states.
The arm orientation of chromosomes 4A, 5A, and 5B presented here is in opposite orientation to the published consensus map (Cavanagh et al. 2013).
Gardano and Dabnichki [ 7] noticed that, in addition to the pitch angle having the influence on drag force, at the high Reynolds numbers (which swimmers usually undergo in the competitions), two main factors affect the drag force: shape and arm orientation.
The distinctions are made on basis of the relative position of the active site elements (switch 1 and switch 2 closed or open; Figure 6(b)), the lever arm orientation (up or down), and the conformation of the actin-binding cleft (open, closed, or partially closed).
S1 crystal structures depicting myosin conformation in M** [ 53] and M* [ 17] lever-arm orientation states indicate G701 swivels 40-50 deg about two axes with the lever-arm swing [ 54].
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