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The estimates using complete MMISS implied an average decrease of 0.13 in the intervention arm compared with the control arm (equivalent to 2.6 points on the original scale).
This equates to only 4% higher usage in the intervention arm, equivalent to an additional cost of about £2, so we assumed equal rates of antihypertensive use in the long term model.
Assuming therefore a conservative 1000 eligible patients per practice of average list size 6000, and adjusting for clustering of patients within practices, assuming a conservative ICC of 0.05 [ 43, 44] the sample size required was 27,768 per arm, equivalent to 28 practices per arm.
There is a 12% reduction in the rate of cancers ⩾20 mm in the intervention arm (equivalent to an 18% reduction adjusted for excess diagnosis), and a 11% reduction in node-positive rate (equivalent to a 17% reduction adjusted for excess diagnosis); both these measures have been shown to have a direct relationship with actual relative mortality reduction in randomised trials (Tabar et al, 1996).
Blisters, and the arm equivalent of shin splints, can occur.
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Therefore, between-arms equivalent liver toxicity was an important determinant of our results regarding survival.
The trfA replacement cassette was generated by PCR using pMW010 DNA (5 ng) as template and ODNs 6088 and 6089 (Table 1) that contained homology arms equivalent to those of 6090 and 6091 (Table 1) (Fig. 1B).
CT or MRI was used as the main evaluation method and adequate doses of radiotherapy was given in both arms equivalent to at least 64Gy, with conventional fractionation to the primary lesion.
First, while the trial was powered to detect a difference in physical activity-related EE between trial arms equivalent to 2 metabolic energy equivalent (MET) h/day or approximately 30 min of brisk walking, the sample size was relatively small for a cohort analysis and may not have been large enough to detect smaller but still biologically important differences.
The 95% CI of each study arm was equivalent to 4 28% of the average blood loss of the study arm.
In D. willistoni the glob2 ortholog has most probably been transposed onto chromosomal arm 2R, equivalent to 2L in D. melanogaster (event B, Figure 1).
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