Our first hypothesis, arising from the observation in the earlier FOCUS trial that patients with low topo-1 expression appear to gain no benefit from the addition of irinotecan to LV5FU2 (Seymour et al, 2007; Braun et al, 2008), was supported and remains an intriguing one.
A further aspect of the relation of the outer to the inner magnetosphere arises from the observations of Nishimura et al. (2010) suggesting a relationship between auroral streamers, which are north-south arcs arising from PBIs, and substorm onset in more equatorward regions.
The indirectness arose from the observations that these items result in change of action or behaviour of other professionals/systems that then impact patient care.
The indication for use of antioestrogens in mammary carcinoma arises from the observations that oestrogen is a mitogen in breast cancer and that approximately one-third of patients will respond to endocrine therapy.
One likely explanation arises from the observations that both 2-MeOE2 and related sulphamoylated derivatives cause G2/M arrest in endothelial cells (Lakhani et al, 2003; Newman et al, 2004), inhibit the proliferation of endothelial cells, and the sulphamate derivatives have been shown to induce Bcl-2 phosphorylation and apoptosis in endothelial cells (Newman et al, 2004).
His proposal arises from the observation that, despite setting some of the world's most ambitious goals, Britain's current policy framework for reducing greenhouse gas emissions falls short of legally binding targets and will disproportionately affect the poor.
The puzzle arises from the observation that if the proposition is true, then presumably it is not about Pegasus since it says that Pegasus does not exist.
